clinical outcome of autologous mononuclear cells transplantation for spinal cord injury: a systematic review and meta-analysis

نویسندگان

hamid reza aghayan compliant stem cell manufacturing facility, brain and spinal cord injury research center, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)سازمان های دیگر: brain and spinal cord injury research cente

babak arjmand compliant stem cell manufacturing facility, chronic diseases research center, endocrinology and metabolism research institute, tehran university of medical sciences, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (tehran university of medical sciences)سازمان های دیگر: chronic diseases research center

endocrinology and metabolism research institute,

mohsen yaghoubi clinical knowledge management unit, department of community medicine, iran university of medical science, tehran, iran.سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (iran university of medical sciences)

چکیده

background :cell-based therapies can be used to treat neurological diseases and spinal cord injuries. the aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (bm-mncs) transplantation in patients with spinal cord injuries.   method s: following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to estimate the outcome of bm-mncs transplantation. the percentage of the patients with improved asia scale from one grade to a higher grade was defined as the main outcome. by considering the study design and outcome measurement, two reviewers independently extracted the data.   result s: eight relevant primary studies were found seven qualified studies, with a combined total of 328 patients were assessed by meta-analysis, including 314 asia-a, 13 asia-b, 94 cervical, 227 thoracic and 60 acute injuries. the percentage of the patients’ improvement was tested by meta-analysis through random and fixed models. the overall percentage of all patients’ improved asia scale after a one- year follow-up (95% cis) was 43 (0.27-0.59).   conclusion : data from published trials revealed that encouraging results were achieved by autologous bm-mncs for the treatment of spinal cord injury. however, the number of clinical trials included in the systematic review was too limited to reach a definite conclusion. more qualified clinical trials with standardized methods are needed to truly justify the outcome of this therapeutic modality in sci patients.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Clinical outcome of autologous mononuclear cells transplantation for spinal cord injury: a systematic review and meta-analysis

  Background :Cell-based therapies can be used to treat neurological diseases and spinal cord injuries. The aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (BM-MNCs) transplantation in patients with spinal cord injuries.   Method s: Following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to es...

متن کامل

Clinical outcome of autologous mononuclear cells transplantation for spinal cord injury: a systematic review and meta-analysis

BACKGROUND Cell-based therapies can be used to treat neurological diseases and spinal cord injuries. The aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (BM-MNCs) transplantation in patients with spinal cord injuries. METHODS Following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to estimat...

متن کامل

Chondroitinase ABC Administration in Locomotion Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

Introduction: The present systematic review and meta-analysis aims to conduct a comprehensive and complete search of electronic resources to investigate the role of administrating Chondroitinase ABC (ChABC) in improving complications following Spinal Cord Injuries (SCI). Methods: MEDLINE, Embase, Scopus, and Web of Sciences databases were searched until the end of 2019. Two independent reviewe...

متن کامل

Neural stem/progenitor cell transplantation for spinal cord injury treatment; A systematic review and meta-analysis.

Despite the vast improvements of cell therapy in spinal cord injury treatment, no optimum protocol has been developed for application of neural stem/progenitor cells. In this regard, the present meta-analysis showed that the efficacy of the neural stem/progenitor cell (NSPC) transplantation depends mainly on injury model, intervention phase, transplanted cell count, immunosuppressive use, and p...

متن کامل

Cell Transplantation for Spinal Cord Injury: A Systematic Review

Cell transplantation, as a therapeutic intervention for spinal cord injury (SCI), has been extensively studied by researchers in recent years. A number of different kinds of stem cells, neural progenitors, and glial cells have been tested in basic research, and most have been excluded from clinical studies because of a variety of reasons, including safety and efficacy. The signaling pathways, p...

متن کامل

Schwann Cells Transplantation Improves Locomotor Recovery in Rat Models with Spinal Cord Injury: a Systematic Review and Meta-Analysis.

BACKGROUND/AIMS Schwann cells (SCs) which were demonstrated to be responsible for axonal myelination and ensheathing are widely studied and commonly used for cell transplantation to treat spinal cord injury (SCI). We performed this meta-analysis to summarize the effects of SCs versus controls for locomotor recovery in rat models of traumatic SCI. METHODS Studies of the BBB scores after transp...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
medical journal of islamic republic of iran

جلد ۲۸، شماره ۱، صفحات ۷۳۵-۷۴۶

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023